Many "unblocked games" sites are riddled with malicious ads, drive-by downloads, or infected executables. Since the full game is not a browser game (except for the original 2011 Flash demo), any site offering the full game is likely distributing tampered files.
and why this basement-crawling adventure is still worth your time. Why Play The Binding of Isaac? The Binding Of Isaac Unblocked Games
Schools and businesses commonly block The Binding of Isaac for three reasons: Many "unblocked games" sites are riddled with malicious
If a website promises The Binding of Isaac: Repentance (the final, massive DLC) for free in a browser, it is 100% a scam. Repentance is a 2GB+ game that cannot run efficiently in pure HTML5. The Binding Of Isaac Unblocked Games