A: Technically yes, but it is not recommended. Upgrade to 14.3 RU1 first, then to RU10. Direct jumps often break database schemas.
If you download and deploy SEP 14.3 RU10 today, you can later migrate to SES without reinstalling agents. The current RU10 agent supports a "re-home" command to point from your on-prem SEPM to the Broadcom cloud. symantec endpoint protection 14.3 ru10 download
Mara traced its call stack and found an orphaned module from an old exploit, one patched years ago. Somehow the attacker had stitched together skeletons from old breaches into a new puppet. RU10's small hardening around process isolation caught the attacker's hand; a thread that used to slip through now snapped. A: Technically yes, but it is not recommended