Verdict: ENABLE IT by default. Your CPU has cores to spare. The performance headroom is worth the minor risk of a graphical glitch in 1 out of 20 games. If a game crashes, simply disable it for that specific game.
: The latest updates ensure better scaling with modern multi-core processors. mtvu pcsx2 upd
While beneficial for most, MTVU can cause instability in specific games: MTVU: VIF1 DMA transfers block the EE-thread #3024 - GitHub Verdict: ENABLE IT by default