. While the keyboard might be recognized as a basic MIDI input device (class-compliant), the advanced HyperControl features usually require kernel-level drivers that do not work on Apple Silicon (M1/M2/M3) or newer Intel Macs. Legacy macOS (10.6 - 10.11): You can still find original drivers on the M-Audio Support Downloads

While the basic MIDI works without drivers, the HyperControl feature—which automatically maps the 49 keys, sliders, and knobs to your DAW—requires separate DirectLink software . 2. macOS Compatibility & Support Status

: You can simply connect the Axiom Pro 49 to your Mac via USB. It should be automatically recognized by the macOS Audio MIDI Setup Driver Availability